Principal Component and Interacting QTL Analyses Identify Novel Gene Loci Associated with Metabolic Traits in Mice
نویسندگان
چکیده
منابع مشابه
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass ind...
متن کاملGenome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.
This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothiazide monotherapy. A genome-wide meta-analysis of blood pressure (BP) response to hydrochlorothiazide was performed in 1739 white hypertensives from 6 clinical trials within the International Consortium for Antihypertensive Pharmacogenomics Studies, making it the largest study to date of its kind....
متن کاملInternal Traits of Eggs and Their Relationship to Shank Feathering in Chicken Using Principal Component Analysis
Chicken eggs represent an important source of protein to the growing human population and also supply repositories of unique genes that could be used worldwide. The inheritance of shank feathering trait is dominant upon non-feathering shank trait in chicken which is based on two factors: pti-1L and pti-1B that are located on Chromosomes 13, 15, and 24. Using 185 fertile eggs collected from two ...
متن کاملHuman-specific CpG “beacons” identify loci associated with human-specific traits and disease
Regulatory change has long been hypothesized to drive the delineation of the human phenotype from other closely related primates. Here we provide evidence that CpG dinucleotides play a special role in this process. CpGs enable epigenome variability via DNA methylation, and this epigenetic mark functions as a regulatory mechanism. Therefore, species-specific CpGs may influence species-specific r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2010
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.09-0547